INFLUENCE OF METHYLENE BLUE IN THE CLINICAL SIGNS OF HORSES WITH EXPERIMENTAL OBSTRUCTION OF JEJUNUM ASSOCIATED TO THE EXPOSITION TO LIPOLISACHARIDE (LPS).

A. D. P. URIBE, C. A. A. VALADÃO, A. E. SANTANA

Abstract



 



 



 





Expressions of pain exacerbated make the early diagnosis of abdominal disorders that compromise the small intestine is of vital importance. The objective of this test was to study the effects of methylene blue on the clinical response before and after the experimental obstruction of the jejunum. Eight male horses, Mangalarga Paulista, with weights ranging between 350 and 400 kg, were exposed to LPS and then were submitted to experimental obstruction of the jejunum. On 4 animals, group 1 (G1), was administered, intravenously, a solution of methylene blue, 1%, immediately before the experimental obstruction. In other 4 animals, Group 2 (G2), the solution was administered immediately before interrupt the obstructive process in the intestinal segment. The horses were submitted to the evaluation of clinical signs during the 12 hours of study. Based on the clinical findings concluded that, the administration of methylene blue controlled more efficiently the clinical changes induced by the experimental model proposed in animals that received the solution immediately before clearing the jejunum.



KEY-WORDS: 

 

 
Jejunum. Equine. Ischemia. LPS. Methylene blue.



DOI: http://dx.doi.org/10.15361/2175-0106.2008v24n3p148-152