EFFECT OF DIETARY SUPPLEMENTATION WITH ASTAXANTHIN ON THE HEMATOLOGICAL AND BIOCHEMICAL RESPONSE OF NILE TILAPIA (Oreochromis niloticus)

Autores

  • M. F. ARACATI Universidade Estadual Paulista "Julio de Mesquita Filho"
  • S. L. OLIVEIRA Unesp/FCAV
  • L. F. RODRIGUES Unesp/FCAV
  • C. C. COSTA Unesp/FCAV
  • G. CONDE Unesp/FCAV
  • B. J. CAVALLI University Brazil
  • H. C. P. SILVA University Brazil
  • B. C. C. IBELLI University Brazil
  • V. L. SCARABEL University Brazil
  • I. C. SILVA University of São Paulo (USP)
  • M. A. A. BELO University Brazil; UNESP/FCAV

DOI:

https://doi.org/10.15361/2175-0106.2021v37n4p285-291

Resumo

This study aimed to evaluate the effect of astaxanthin on the hematological, biochemical and somatic response of Nile tilapia (Oreochromis niloticus) orally administered in the feed for a period of 60 days. For the study, 105 tilapia (n=35) from the same spawn were used, constituting the following treatments: Control = animals (not treated with astaxanthin); T100 and T200 = fish treated with 100 and 200 mg of astaxanthin/kg of feed, respectively. There were no hematological alterations in red blood cells counts, hematocrit, hemoglobin, MCV and MCHC. In addition, astaxanthin-fed tilapia presented a better thrombocyte and leukocyte responses with a marked decrease in the number of thrombocytes, lymphocytes and neutrophils. Among treatments, there were no changes in serum levels of total protein, albumin, globulins, aspartate aminotransferase and alkaline phosphate. Treatment with astaxanthin resulted in a decrease in triglyceride and glucose levels, as well as increase in hepatosomatic indices. The results of hematological and biochemical analyzes of tilapias demonstrated the clinical safety of this carotenoid, not causing harmful effects to the health of fish. Therefore, the antioxidant activity of this compound in tilapias resulted in an improvement in the leukocyte profile and contributed to hypolipidemic effects at the dose of 200mg of astaxanthin/kg of feed.

Biografia do Autor

M. F. ARACATI, Universidade Estadual Paulista "Julio de Mesquita Filho"

Formação em Medicina Veterinária pela Universidade Brasil em 2018. Durante a graduação foi bolsista de iniciação cientifica da Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP, Brasil (Processo: 2017/03094-7) durante 1 ano e 6 meses. Foi Estagiária do Laboratório de Farmacologia e Toxicologia Animal (2016-2018), além de colaboradora no desenvolvimento de projetos do Grupo de pesquisas (GAP) na área de fisiopatologia do processo inflamatório em peixes teleósteos. Atualmente é Mestra pela Universidade Estadual Paulista "Julio de Mesquita Filho" campus Jaboticabal (FCAV) na area de Medicina Veterinária Preventiva.

S. L. OLIVEIRA, Unesp/FCAV

Preventive veterinary medicine department

L. F. RODRIGUES, Unesp/FCAV

Preventive veterinary medicine department

C. C. COSTA, Unesp/FCAV

Preventive veterinary medicine department

G. CONDE, Unesp/FCAV

Preventive veterinary medicine department

B. J. CAVALLI, University Brazil

Laboratory of Animal Pharmacology and Toxicology

H. C. P. SILVA, University Brazil

Laboratory of Animal Pharmacology and Toxicology

B. C. C. IBELLI, University Brazil

Laboratory of Animal Pharmacology and Toxicology

V. L. SCARABEL, University Brazil

Laboratory of Animal Pharmacology and Toxicology

I. C. SILVA, University of São Paulo (USP)

Department of Pharmacology, Institute of Biomedical Sciences

M. A. A. BELO, University Brazil; UNESP/FCAV

Laboratory of Animal Pharmacology and Toxicology; Department of Preventive Veterinary Medicine 

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Publicado

22/12/2021

Edição

Seção

Physiology and Pharmacology/Fisiologia e Farmacologia