CORRELATION BETWEEN PLASMA CONCENTRATION OF VILOCCI, A CEFTIOFUR FORMULATION, AND MINIMUM INHIBITORY CONCENTRATION VALUES OF ZOOTECHNICAL INTEREST MICROORGANISMS IN CATTLE AND PIGS

Abstract

Ceftiofur is a third-generation cephalosporin widely used in cattle and swine farming to treat respiratory and reproductive conditions. The veterinary pharma industry consistently develops new formulations with this molecule to bring highly effective products to market with short withdrawal periods, ensuring consumer safety for products derived from treated animals.

This study aimed to evaluate the plasma concentration profile of Vilocci, a new formulation of ceftiofur, in comparison to the minimum inhibitory concentrations (MIC) of various pathogens commonly found in bovine and swine farming. Ten animals from each species were used, and a single dose of 1 mg/kg was given to bovines and 5 mg/kg to swine. Blood samples were collected at 12 time points to construct the pharmacokinetic profile.

In addition, the minimum inhibitory concentration (MIC) of growth for the pathogens of interest isolated from the target species was determined. The effectiveness of Vilocci (Ceftiofur hydrochloride 50mg/mL) against each of the evaluated pathogens was also assessed.